Rosucard instructions for use and for what

Release form, composition

The manufacturer of the drug is the Czech Republic. The active ingredient of the drug is rosuvastatin. The following are used as auxiliary components:

• microcrystalline cellulose;
• lactose monohydrate;
• magnesium stearate;
• croscarmellose sodium.

Release form: pink film-coated tablets. They have a characteristic notch. The dosage is different - 10 mg, 20 mg and 40 mg. The number of tablets in a package is variable: packages containing 10, 30, 60 and 90 pieces are offered.

Rosecard price

The price of Rozucard is considered very affordable compared to many analogues. The exact cost of the drug depends on the content of the active substance in the tablets. Thus, the price of Rosucard 10 mg in a package with 3 plates is about 500 rubles in Russia or 100 hryvnia in Ukraine. And the price of Rosucard 20 mg in a package with 3 plates is approximately 640 rubles in Russia or 150 hryvnia in Ukraine.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Rosucard tablets p.p.o.
  20 mg 30 pcs. Zentiva s.s. RUB 861 order
• Rosucard tablets p.p.o. 10 mg 30 pcs. Zentiva s.s.

  RUR 562 order

• Rosucard tablets p.p.o. 40 mg 30 pcs. Zentiva s.s.

  RUB 1,177 order

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• Rosucard tablets p.p.o. 40 mg 90 pcs. Zentiva s.s.

  RUB 2844 order

• Rosucard tablets p.p.o. 20 mg 90 pcs. Zentiva s.s.

  RUR 2,005 order

Pharmacy Dialogue

• Rosacard tablets 20 mg No. 60Zentiva

  RUB 1,419 order

• Rosacard tablets 10 mg No. 60Zentiva

  979 RUR order

• Rosacard tablets 20 mg No. 30Zentiva

  RUB 899 order

• Rosacard tablets 20 mg No. 90Zentiva

  RUB 2,082 order

• Rosacard tablets 10 mg No. 90Zentiva

  RUB 1,426 order

Europharm* 4% discount using promo code medside11

• Rosucard 20 mg 30 tablets Zentiva s.s.

  RUR 923 order

• Rosucard 10 mg 30 tablets Zentiva s.s. Czech Republic

  RUR 706 order

• Rosucard 10 mg 90 tablets Zentiva s.s.

  RUB 1,764 order

• Rosucard 20 mg 90 tablets Zentiva s.s.

  RUB 2,188 order

• Rosucard 20 mg 60 tablets

  RUB 1,762 order

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Pharmacy24

• Rosecard 10 mg No. 30 tablets TOV Zentiva, Czech Republic
  139 UAH.order
• Rosecard 20 mg No. 30 tablets TOV Zentiva, Czech Republic

  190 UAH order

• Rosecard 40 mg No. 30 tablets TOV Zentiva, Czech Republic

  340 UAH. order

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• Rosacard 20 mg N90 tablets TOV Zentiva, Czech Republic

  506 UAH order

• Rosacard 10 mg N90 tablets TOV Zentiva, Czech Republic

  304 UAH order

Pharmacology

The maximum presence of the active substance in the blood serum after taking a dose of the drug is observed after 5 hours. Bioavailability of the drug is approximately 20%. Course use does not have any serious effect on the process of drug absorption. The binding of statin to blood proteins reaches 90%. The absorption of Rosucard occurs in the liver tissues.

The drug is excreted naturally: 10% with urine, the remaining 90% with feces. The primary therapeutic effect is observed on the seventh day from the start of treatment. The maximum is achieved by the end of the second week of regular use.

Pharmacodynamics and pharmacokinetics

Rosucard belongs to the group of statins. It inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate.

In addition, this drug increases the number of LDL receptors on hepatocytes, which increases the intensity of LDL catabolism and uptake and causes inhibition of VLDL synthesis, reducing the total content of VLDL and LDL. The drug reduces the concentration of LDL-C, high-density non-lipoprotein cholesterol, VLDL-C, TG, apolipoprotein B, VLDL-TG, total cholesterol, and also increases the content of ApoA-1 and HDL-C. In addition, it reduces the ratio of ApoB and ApoA-1, non-HDL-C and HDL-C, LDL-C and HDL-C, total cholesterol and HDL-C.

The main effect of Rosucard is directly proportional to the prescribed dosage. The therapeutic effect after the start of treatment is noticeable within a week, after about a month it becomes maximum, and then strengthens and becomes permanent.

The maximum concentration of the main active substance in plasma is established after 5 hours. Absolute bioavailability is 20%. The degree of binding to blood plasma proteins is about 90%.

With regular use, the pharmacokinetics do not change.

Rosucard is metabolized through the liver. Penetrates well through the placental barrier. The main metabolites are N-dismethyl and lactone metabolites.

The half-life is approximately 19 hours, and it does not change if the dosage of the drug is increased. Plasma clearance on average is 50 l/h. Approximately 90% of the active substance is excreted unchanged through the intestines, the rest through the kidneys.

Gender and age do not affect the pharmacokinetics of Rosucard. However, it depends on race. In Indians, the maximum concentration and mean AUC value are approximately 1.3 times higher than in Caucasians. AUC in people of the Mongoloid race is 2 times higher.

Indications for use

Indications for use of Rosucard:

• hypercholesterolemia (primary) and dyslepidemia (mixed) - the drug is prescribed as a supplement to the prescribed therapeutic diet;
• atherosclerosis - allows you to slow down the progression of pathology, complements the therapeutic diet, allows you to reduce LDL (low-density lipoproteins) to a physiological level;
• familial homozygous hypercholesterolemia – Rosacard is part of the treatment.

Statin can be used as a prophylactic agent to prevent the development of complications of cardiovascular pathologies, as well as the high likelihood of atherosclerosis.

Indications for use of Rosucard

The use of Rosucard is indicated for the following diseases:

• Primary heterozygous (hereditary) hypercholesterolemia according to Fredrickson. In addition to drug therapy, the patient is recommended a low-carbohydrate diet and special exercise to reduce body weight.
• Hereditary homozygous hypercholesterolemia.
• Insufficiency of lipoprotein lipase, which was formed against the background of a defective enzyme and activator of apoprotein CII. This condition often occurs with diabetes.
• As an inhibitor of lipid metabolism disorders and accompanied by the deposition of cholesterol on the inner walls of blood vessels. Therapy with Rosucard helps reduce cholesterol and LDL cholesterol.

The drug is widely recommended for the prevention of cardiovascular diseases (myocardial infarction, stroke, angina, persistent arterial hypertension).

Rosacard also helps patients who have undergone arterial revascularization. Tablets are not prescribed if the patient has symptoms of acute ischemia.

Contraindications

The use of a statin should be discontinued in the following cases:

• individual intolerance to the component composition;
• severe kidney damage;
• acute form of liver pathologies;
• myopathy;
• gestation;
• lactation.

Important! The medication should not be prescribed to women of fertile age who do not take or use contraceptives.

The 40 mg dosage is contraindicated in patients whose lives include factors for the development of rhabdomyolysis and/or myopathy. They are:

What drugs are statins?

• complex renal dysfunction of moderate severity and higher;
• hereditary pathologies of muscle tissue;
• chronic alcoholism;
• hypothyroidism;
• history of myotoxicity caused by taking HMG-CoA reductase inhibitors or fibrates.

The high-risk group also includes representatives of the Mongoloid race and people taking fibrates. A dosage of 40 mg is contraindicated, since it can provoke an excess of the permissible concentration of the active substance in the blood serum.

Side effects

While taking Rosucard, the development of side effects is possible:

• cephalgia;
• dizziness;
• asthenic syndrome;
• cough;
• dyspnea;
• muscle pain;
• swelling;
• increased activity of serum CPK (creatine phosphokinase);
• attacks of nausea;
• stomach ache;
• stool disorders;
• non-insulin-dependent diabetes mellitus;
• urinary tract infections.

More rarely, pancreatitis, memory impairment, hepatitis, jaundice, peripheral neuropathy, myopathy, the appearance of blood in the urine, increased levels of ALT and AST are formed.

The period of breastfeeding is a contraindication to taking the drug Rosucard

Directions for use and dosage

According to the instructions for use, the tablets are taken whole with the required volume of clean water. You can drink them at any time, without focusing on food intake. How long to take Rosucard is decided by the attending physician. Before starting a course of treatment, the patient must follow a special lipid-lowering diet that helps reduce bad cholesterol levels, and continue to adhere to the principles of dietary nutrition throughout the course.

The dosage of the product is calculated individually. The basis is taken from test indicators that characterize the patient’s current condition. If a person has been prescribed a dosage of 5 mg, then the tablet at a dosage of 10 mg must be divided into two parts. The initial dosage (recommended) is 5/10 mg per day.

Used at the beginning of treatment or in patients who started taking Rosucard as an alternative drug after stopping another inhibitor. The choice of initial dosage is influenced by the current level of blood cholesterol, the likelihood of developing cardiovascular complications, and the risk of side effects.

The selected dosage may be revised upward after 4 weeks from the start of taking the statin. A daily dosage of 40 mg is prescribed in exceptional cases, as it often causes side effects. Indications include severe hypercholesterolemia and a high risk of developing cardiovascular complications. Patients in this case need constant medical supervision.

For liver failure

In case of liver dysfunction, which on the Child-Pugh scale has a score of less than seven points, no dose adjustment is needed.

For renal failure

In mild cases of pathology, no dose adjustments are made. The initial dose is 5 mg per day (1/2 tablet of 10 mg). With moderate severity, characterized by a creatinine clearance level of 30–60 ml/min, high doses of Rosucard (40 mg) are strictly contraindicated. In severe cases, when CC is less than 30 ml/min, taking the medicine is completely prohibited.

Aged people

Patients over 65 years of age do not need to review dosages.

Predisposition to the development of myopathy

Prescribing Rosucard at a dosage of 40 mg in the presence of a predisposition to myopathy is prohibited. Acceptable dosages are 10/20 mg. The initial dose is 5 mg per day.

Ethnic groups

Studies have shown an increase in the concentration of the active substance in people belonging to the Mongoloid race. This must be taken into account when prescribing dosage. Patients can receive 10/20 mg per day. The initial dosage is 5 mg. Prescribing 40 mg is completely contraindicated. If you plan to take Rosucard with gemfibrozil, the dosage should not exceed 10 mg per day.

Pregnancy and breastfeeding period

The period of bearing a child is a contraindication for the use of Rosucard, since both cholesterol itself and the substances released from it are necessary for a growing and actively developing fetus. If a woman is pregnant during a course of taking a statin, treatment must be interrupted immediately.

She should also be warned about the possibility of negative consequences for the fetus. The use of Rosucard should also be avoided during breastfeeding. The active substance can pass into breast milk, causing the baby to develop severe conditions.

Pregnancy and lactation:

The use of Rosucard in women of reproductive age is possible only if reliable methods of contraception are used and if the patient is informed about the possible risk of treatment to the fetus.

Since cholesterol and substances synthesized from cholesterol are important for fetal development, the potential risk of inhibiting HMG-CoA reductase outweighs the benefit of using the drug during pregnancy. Rosucard is contraindicated during pregnancy and lactation. If pregnancy is diagnosed during drug therapy, Rosucard should be stopped immediately, and the patient should be warned of the potential risk to the fetus.

If it is necessary to use the drug during lactation, taking into account the possibility of adverse events in infants, the issue of stopping breastfeeding should be decided.

Many medications can adversely affect the embryo or fetus and even lead to malformations of the unborn child. In addition, drugs taken with mother's milk enter the baby's body and act on it. Therefore, pregnant and breastfeeding women should be very careful when using medications.

Drug interactions

When starting a course of treatment, it is necessary to take into account the drug interaction of Rosucard with other medications.

• Cyclosporine. Helps increase AUC levels.
• Lipid-lowering drugs, in particular Gemfibrozil. The combined use increases the concentration of Rosucard, which leads to an increased risk of developing myopathy. The maximum permissible dose of Rosucard is 20 mg.
• Fibrates. The dose of Rosucard is 5...20 mg. Large dosages are prohibited.
• Protease inhibitors. They cause increased exposure of the active substance. This combination is not used in the treatment of patients with HIV infection.
• Erythromycin. When used together, there is a decrease in the maximum concentration of the active substance of Rosucard by approximately 30%.
• Lopinavir. Increases the AUC and maximum concentration of the active substance of the drug in question.
• Ezetimibe. It is possible that there may be mutual enhancement of side effects.
• Antacids containing aluminum/magnesium hydroxyl. Reduces Rosecard concentration by 50%. Therefore, at least two hours should pass between doses of the drug.
• Oral contraceptives. When using OCs in combination, it is necessary to monitor the woman’s well-being for the development of side symptoms.

Features of application

You can take this medicine only after consulting your doctor! Self-medication leads to undesirable consequences.

Pregnancy and lactation are a direct contraindication to taking statins. For proper development and growth of the fetus, an increased concentration of serum cholesterol is needed. When taking rosuvastatin, the risk to the fetus will be higher than the benefit to the mother.

To avoid the development of side effects of the drug in infants, it should not be taken during lactation. If it is not possible to refuse treatment, it is necessary to interrupt breastfeeding the baby.

Clinical studies of the safety and effectiveness of this medicine for children have not been conducted. Therefore, routine use of Rosucard in pediatric practice is unacceptable.

The acute phase of all inflammatory processes of the hepatic parenchyma is a contraindication to treatment with rosuvastatin. If the patient suffers from chronic liver disease, therapy must be carried out under the strict supervision of specialists!

For persons suffering from severe renal failure, drug therapy is contraindicated. In case of moderate or mild renal parenchymal insufficiency, treatment is possible. A doctor's supervision and timely dose adjustment are required.

What to replace

Analogues of Rosecard are numerous. If necessary, you can purchase both expensive and cheap products from different manufacturers at the pharmacy.

Which analogue of the drug is better and what can be used to replace Rosucard should be decided by the attending physician.

Rozart is one of the substitutes for Rosuvastatin

Analogues of Rosucard, list of drugs

Important - instructions for use of Rosucard, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic prescriptions must be made by a doctor. When replacing Rosucard with an analogue, it is important to consult a specialist; you may need to change the course of therapy, dosages, etc.

Modern doctors prescribe Rosucard to patients, instructions for use, price, reviews and analogues of which are discussed below. The information below about the drug will also answer the question: “What is Rosucard prescribed for?”

There are many substitutes for the drug. Russian analogues of the drug will cost less than their foreign competitors.

You can replace Rosucard with Crestor, Rozart, Rozulip, Mertenil, Atorvastatin, Roxera. Without knowing pharmacology, it is difficult to understand which medicine is considered the best Liprimar or Rosuvastatin. The doctor will be able to answer what is best for a particular patient. Therefore, before using any of the Rosucard analogues, you should consult your doctor!