Anaprilin - instructions for use, indications, contraindications

1321

The drug Anaprilin is intended to reduce the strength and frequency of heart contractions, as well as to reduce cardiac output. As a result of the action of the drug, the heart rhythm during tachycardia is normalized and the heartbeat improves (interruptions in the functioning of the heart muscle are reduced).

The drug is dispensed only as prescribed by the attending physician or cardiologist.

Release form and composition

It is produced in the form of tablets of 10 and 40 mg, as well as a solution for administration into a vein in ampoules of 1 and 5 ml.
The active component of Anaprilin is propranolol. Auxiliary ingredients such as talc, sugar, starch, and calcium stearate help improve the absorption of the active substance. Along with the medicine in the box there are instructions for use. The dosage form of Anaprilin is tablets: flat-cylindrical, white, with or without a score, with a chamfer (in blister packs of 10 pcs., in a cardboard pack 1, 3 or 5 packs; 15 pcs each, in a cardboard pack 1 or 2 packages, 20 pieces each, 1 package in a cardboard box; 50 or 100 pieces in orange glass jars, 1 jar in a cardboard box).

The active substance is propranolol, 1 tablet contains 10 or 40 mg.

Auxiliary components: milk sugar, potato starch, calcium stearate, talc.

The main active substance is propranolol hydrochloride.

Excipients:

starch;
calcium stearate;
hypromellose;
cellulose;
talc;
silica.

Anaprilin is produced in the form of tablets in doses of 10 mg and 40 mg, 10, 50, 100 capsules per package. An injectable form of drug release has also been developed.

Analogs

The price of the drug varies depending on the number of tablets in the package. The average cost of a package (50 tablets, 10 mg) is 20 rubles. If the dosage is increased to 40 mg and the total number of tablets to 112, the price of the drug will be from 50 to 70 rubles.

Among similar drugs, there are both generics (based on pronanolol) and drugs of the beta-blocker group with another active ingredient. Among the generics, Propamin, Stobetin, Phenazep, Obzidan, Noloten, Anaprinol, Betake, Propranobene should be highlighted. Many of these medications have almost the same list of contraindications and side effects as Anaprilin.

The latest generation drugs are full-fledged substitutes for propanolol, and in terms of effectiveness they can be superior to the original drug. However, their cost is also higher. Similar analogues include Bisoprolol, Metoprolol, Betaxolol, Atenolol, Nebivolol, Concor, Aritel, Bidop, Bisomore, Bisocard and others.

Drug interactions

digestive system: nausea, vomiting, diarrhea/constipation, dry mouth, liver dysfunction, change in taste, pain in the epigastric region;
respiratory system: nasal congestion, rhinitis, bronchospasm, shortness of breath, laryngospasm;
sensory organs: decreased secretion of tear fluid (dry eyes), keratoconjunctivitis, impaired visual acuity;
skin: psoriasis-like skin reactions, exacerbation of psoriasis, alopecia, increased sweating, skin hyperemia, exanthema;
cardiovascular system: atrioventricular block, palpitations, arrhythmias, orthostatic hypotension, peripheral arterial spasm, sinus bradycardia, heart failure, myocardial conduction disturbance, decreased blood pressure (BP), chest pain, cold extremities;
nervous system: in rare cases - insomnia/drowsiness, asthenic syndrome, agitation, paresthesia, weakness, short-term memory loss or confusion, tremor, headache, depression, fatigue, dizziness, hallucinations, decreased ability for rapid motor and mental reactions;
metabolism: hypoglycemia (in patients with type 2 diabetes mellitus);
reproductive system: decreased potency, decreased libido;
endocrine system: decreased thyroid function;
allergic reactions: itching, skin rash;
effect on the fetus: intrauterine growth retardation, bradycardia, hypoglycemia;
laboratory parameters: increased bilirubin, agranulocytosis;
other: pain in the back and joints, in the chest, muscle weakness, thrombocytopenia, leukopenia.

Anaprilin should not be taken together with tranquilizers and neuroleptics (antipsychotic drugs).

Due to a possible sharp decrease in blood pressure, it is not recommended to take ethanol-containing drugs during treatment.

The hypotensive effect of the drug is enhanced by the simultaneous use of reserpine, hydrochlorothiazide, hydralazine and other antihypertensive drugs, weakened by the use of estrogens, non-steroidal anti-inflammatory drugs, MAO inhibitors (the interval between taking propranolol and monoamine oxidase inhibitors should not be less than 14 days).

When taken together with antihistamines, Anaprilin reduces their effect, and when taken with uterotonic and thyreostatic drugs, it enhances it.

When administered simultaneously with phenothiazine derivatives, the concentration of both drugs in the blood plasma increases, and with cimetidine, the bioavailability of cimetidine increases.

Non-hydrogenated ergot alkaloids increase the risk of developing peripheral circulatory disorders.

Rifampicin - reduces the half-life, sulfasalazine - increases the concentration of propranolol in the blood plasma.

Anaprilin is well absorbed into the bloodstream. The half-life of propranolol is 3-5 hours; with long-term use of the drug, this time reaches 12 hours. Being absorbed, propranolol is excreted by the kidneys as a metabolite (90%), about 1% remains unchanged.

Indications for the use of Anaprilin - what the medicine helps with in accordance with the instructions for use:

heart rhythm disorders caused by rheumatic heart diseases;
angina pectoris;
ischemia;
hypertension;
thyrotoxicosis (as an auxiliary drug);
pheochromocytoma (use in combination with α-blockers).

Anaprilin is a drug of synthetic origin, belonging to the group of non-selective β-blockers, which mainly affects the cardiovascular system.

The main therapeutic properties of the drug are antiarrhythmic, hypotensive, antianginal. This involves the use of Anaprilin for tachycardia, arrhythmia, and other cardiac disorders. Upon entering the body, the drug is quickly absorbed into the blood and provides the following effects:

decreased strength and frequency of contractions of the heart muscle;
decreased oxygen demand of the heart;
decrease in the amount of blood taken from the heart;
decreased blood pressure;
increased peripheral vascular resistance;
increased tone of smooth bronchial muscles;
sedation (in high doses).

The treatment is well tolerated; as a rule, there are no serious complications during therapy. But sometimes the use of propranolol can cause unwanted side effects, including:

sinus bradycardia;
poor circulation (limbs may go numb);
severe hypotension;
worsening progression of heart failure;
headaches, dizziness;
nausea;
sleep disorders;
mental disorders - depression, slow psychomotor and motor response;
cough, shortness of breath, pharyngitis, bronchospasm, laryngospasm;
dyspepsia, abdominal pain;
skin manifestations;
alopecia;
dryness, pain in the eyes;
visual impairment;
decreased libido.

Anaprilin cannot be used simultaneously with sedatives and antipsychotics. It is not recommended to take the medicine in combination with hypoglycemic drugs. The compatibility of Anaprilin with Verapamil is also unfavorable.

It is important to keep in mind that during the use of Anaprilin, attention and reaction may be impaired, so persons engaged in work that requires attention and quick response require special caution. During therapy, it is necessary to monitor the glycemic level!

Unlike unfavorable combinations, Anaprilin is combined with Atarax (a histamine blocker).

In addition to possible contraindications, doctors need to know what medications you are currently taking. Anaprilin will not work with some of them. This is especially important if you take medications that lower blood pressure.

Examples of negative interactions:

Anaprilin halaperidol – severe arterial hypotension (sharp decrease in blood pressure);
Lithium carbonate Anaprilin – risk of developing bradycardia;
Anaprilin is a means for injection anesthesia - the risk of suppressing myocardial function and aggravating hypertension increases.

Undesirable effects are numerous. If you called an ambulance and the doctor decided to give you Anaprilin, be sure to list the medications that you are currently using.

Interaction with other drugs

The simultaneous use of Propanolol with other medications should be strictly monitored by the attending physician, since the active substance can weaken or enhance the pharmacological effect of the drugs. The interaction of the drug has been studied in the following cases:

Strengthening the anesthetic and antiarrhythmic effects of Lidocaine and Bupivacaine.
Increased concentrations of Warfarin and Phenindione when used simultaneously.
Increased antihypertensive effect of Clonidine.
Risk of developing bradycardia when combined with lithium carbonate.
Inhibitory effects on the activity of the heart muscle, as well as on blood pressure when taking Diltiazem.
Leveling the therapeutic effects of Amiodarone and the occurrence of symptoms of asystole, bradycardia, hypotension and ventricular fibrillation.
The simultaneous use of propafenone or Imipramine and Propanolol increases the concentration of the latter.
Taking antihypertensive drugs (for example, Reserpine, Hydralazine, Hydrochlorothiazide) provokes an increase in the hypotensive effect of Anaprilin. The use of MAO inhibitors, nonsteroidal anti-inflammatory drugs, and estrogens reduces the hypotensive effect.
The combination of the drug with Haloperidol or with sodium amidotrizoate can cause severe arterial hypotension.

Propanolol hydrochloride is strictly contraindicated when taking tranquilizers, antipsychotics and other antipsychotic drugs. It is also necessary to exclude ethanol-containing drugs to avoid the development of hypotension and arrhythmia. And taking Egginephrine, Dobutamine and Isoproterenol can reduce the therapeutic effect of Anaprilin to zero.

Pharmacological properties

Pharmacodynamics

Propranolol is a non-selective β-blocker with antianginal, antiarrhythmic and antihypertensive effects. Due to non-selective blocking of β-adrenergic receptors (75% - β1- and 25% - β2-adrenergic receptors), the formation of cyclic adenosine monophosphate (stimulated by catecholamines) from adenosine triphosphate is reduced.

At the beginning of therapy, total peripheral vascular resistance increases over 24 hours (associated with a reciprocal increase in the activity of α-adrenergic receptors and the elimination of stimulation of β2-adrenergic receptors in skeletal muscle vessels). After 1–3 days, this indicator returns to the original value, and with long-term treatment it decreases.

Mechanism of action of Anaprilin:

antianginal effect: associated with a decrease in myocardial oxygen demand (due to negative chrono- and inotropic effects). By reducing the number of heart contractions, diastole is lengthened and myocardial perfusion is improved. An increase in end-diastolic pressure in the left ventricle and an increase in the stretching of the muscle fibers of the ventricles of the heart cause an increase in oxygen demand, especially in patients with chronic heart failure;
antihypertensive effect: associated with a decrease in minute blood volume, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin-aldosterone system (important for patients with initial hypersecretion of renin), sensitivity of the baroreceptors of the aortic arch (in response to a decrease in blood pressure, an increase in their activity is not observed) and effects on the central nervous system. Stabilization of the antihypertensive effect occurs by the end of a two-week course of use;
antiarrhythmic effect: associated with the elimination of arrhythmogenic factors (arterial hypertension, increased activity of the sympathetic nervous system, tachycardia, increased content of cyclic adenosine monophosphate), slowing down atrioventricular conduction and reducing the rate of spontaneous excitation of sinus and ectopic pacemakers. Inhibition of impulse conduction is observed mainly in the antegrade and to a lesser extent in the retrograde directions. According to the classification of antiarrhythmic drugs, it belongs to group II drugs.

Main effects of Anaprilin:

prevention of the development of migraine of vascular origin (associated with a decrease in the severity of dilatation of cerebral arteries due to β-blockade of vascular receptors, a decrease in platelet adhesiveness, inhibition of platelet aggregation and lipolysis caused by catecholamines, a decrease in renin secretion and stimulation of oxygen supply to tissues);
reduction in the severity of myocardial ischemia, post-infarction mortality (occurs due to the antiarrhythmic effect due to a decrease in myocardial oxygen demand);
increased bronchial tone;
reduction of tremor (associated mainly with blockade of peripheral β2-adrenergic receptors);
increased contractions of the uterus (spontaneous or associated with the use of drugs that stimulate the myometrium);
increasing the atherogenic properties of blood.

Pharmacokinetics

Propranolol, when taken orally, is absorbed quickly and to a fairly complete extent (90%), and is excreted from the body at a relatively high rate. Bioavailability after oral administration is 30–40% (associated with the effect of primary passage through the liver, microsomal oxidation), this figure increases with long-term therapy (metabolites are formed that inhibit liver enzymes). The amount of bioavailability is determined by the nature of the food and the intensity of hepatic blood flow.

The time to reach maximum concentration in blood plasma is from 1 to 1.5 hours. It is highly lipophilic and accumulates in the tissues of the lungs, brain, heart, and kidneys.

Propranolol penetrates the blood-brain and placental barriers, as well as into breast milk. The volume of distribution ranges from 3 to 5 l/kg. Plasma protein binding is 90–95%.

Propranolol is metabolized in three ways - aromatic hydroxylation, N-dealkylation, glucuronidation in the liver (including with the participation of cytochrome isoenzymes CYP2D6, CYP1A2, CYP2C19). It enters the intestine with bile, where it is deglucuronidated and reabsorbed, and therefore the half-life during a course of treatment can be extended to 12 hours.

In case of impaired renal/hepatic function and in elderly patients, the plasma concentration of the drug in the blood increases, and the half-life lengthens.

The main route of elimination is the kidneys (about 90%), up to 1% is excreted unchanged. The half-life is 3–5 hours. It is not removed by hemodialysis.

What recommendations are indicated in the instructions for use of Anaprilin, at what pressure is the medicine taken? Anaprilin for blood pressure is used for hypertension to correct high blood pressure levels. The effect appears within 1–2 weeks after starting treatment. Not recommended for low blood pressure and high blood pressure.

When it comes to taking Anaprilin - what it helps with and how to take the medicine - the most important factors are the conditions accompanying arterial hypertension, i.e. high blood pressure:

sinus, supraventricular and ciliary tachycardia;
ischemia;
angina pectoris;
thyrotoxicosis;
cardiopathy.

The main active substance, propranolol, affects both types of receptors - β1 and β2 (adrenergic receptors that do not have a selective effect). As a result, the membrane is stabilized, the sympathetic impulse to the myocardial receptors is weakened, and the heart rhythm is normalized. Cardiologists recommend the use of Anaprilin for recovery in the post-infarction period.

It should be borne in mind the difference in the reaction of the body of young and elderly patients. Older people react to the drug differently - a decrease in vascular tone when using the drug can cause bronchospasm and pulmonary edema. Therefore, the dosage of the drug for people over 58–60 years of age is selected individually, depending on the body’s reactions.

The drug "Anaprilin" has a hypertensive effect and helps with abnormalities in the functioning of the cardiovascular system. Blood pressure drops after a single dose of the medication, and after 3 weeks of therapy, patients experience a sustained antihypertensive effect. If cardiac ischemia is diagnosed, angina attacks occur much less frequently after using the drug, and the need for taking Nitroglycerin is reduced.

Anaprilin is indicated for use with high blood pressure, the values of which are 140 and above.

Anaprilin tablets - instructions for use

The pharmacological drug Anaprilin is a non-selective beta-blocker that interferes with signal transmission in receptors of the cardiovascular system. The medicine reduces the pulse rate and its strength. It reduces the amount of blood that is released from the heart chambers into the vessels in one contraction. In this case, the myocardium is not damaged even with prolonged use of the drug.

The drug is available in the form of tablets in a plastic blister of 10 pieces in a cardboard package with instructions for use. The standard amount of active substance in one tablet is 10 mg. The dose for drug therapy of the patient is selected depending on the severity of the condition and the type of other pharmacological drugs prescribed simultaneously with Anaprilin.

Compound

The drug contains one active ingredient – propranolol. The quantity and composition of additional ingredients, which serve to improve absorption in the intestines, give the tablet shape and improve taste, depend on the manufacturer. One tablet of Anaprilin contains:

Substance name	Amount, mg
Propranolol	10
Talc	5
Potato starch	15
Additional substances (milk sugar)	3

Properties of the drug

The drug reduces the rate of automatism of the sinus node, the general excitability of the myocardium, reduces contractility and the need for oxygen in cardiac tissue. The drug has the property of reducing pressure in the peripheral areas of blood vessels, increasing contractions of the muscles of the uterine wall, increasing bronchial tone, having a slight sedative effect, and reducing intraocular pressure.

The drug is quickly absorbed into the bloodstream through the wall of the small intestine when taken orally. The maximum concentration of the main active ingredient in plasma is reached after approximately one and a half hours. Bioavailability for the tablet form of the drug is about 35-40%, while binding to blood proteins is 90%. The half-life after food intake is approximately 3-4 hours.

Complete clearance of the pharmacological drug is achieved within a day. The active substance (propranolol) breaks down into metabolites under the action of liver enzymes. Derivative drugs are primarily excreted by the kidneys, partly with feces, bile and sweat. The active component of the drug penetrates the placental and blood-brain barriers, so Anaprilin can negatively affect the fetus during pregnancy.

What are Anaprilin tablets for?

The medicine Anaprilin is prescribed for cardiovascular diseases, attacks of tachycardia and arrhythmia. The drug helps with arterial hypertension and hypertensive crises. The medication is actively used for complex pharmacological treatment of heart failure, myocardial infarction, and capillary pathologies. The active substance of the drug helps to reduce the tone of the muscle component of the vascular wall, resulting in a decrease in pressure and a decrease in the frequency of ischemic attacks.

The drug is effective for relieving bronchospasm in asthmatic disease. Anaprilin is successfully used for drug therapy of angina attacks and hereditary heart rhythm pathologies. If you have a predisposition to cancer of the cardiovascular system, the drug helps slow down the division of cancer cells. Due to the high degree of purification of the main active ingredient, Anaprilin is successfully used to prevent attacks of coronary heart disease and hypertension in the elderly.

Articles on the topic

Omnik - instructions and mechanism of action, contraindications, side effects, dosage regimen and analogues
Dalatsin - instructions and reviews
Antiarrhythmic drugs - classification and principle of action, list of the best medicines

Contraindications

unstable angina;
angina pectoris;
various heart rhythm disturbances associated with rheumatic heart lesions (arrhythmia, atrial fibrillation, paroxysmal and sinus tachycardia, extrasystole);
hypertonic disease;
pheochromocytoma (Anaprilin is used with alpha-blockers);
arterial hypertension;
migraine prevention;
alcohol withdrawal (shaking and agitation);
thyrotoxic crisis and diffuse toxic goiter - as an adjuvant, including in case of intolerance to thyreostatic drugs.

Taking Anaprilin also allows you to increase uterine contractions and reduce bleeding during childbirth and in the postoperative period.

acute heart failure;
myocardial infarction in the acute stage;
sinoatrial block;
AV block II–III degree;
sick sinus syndrome;
metabolic acidosis;
arterial hypotension;
bronchial asthma;
predisposition to bronchospasm;
spastic colitis;
sinus bradycardia [heart rate (HR) less than 55 beats/minute];
diabetes;
lactation;
the presence of hypersensitivity to the components of Anaprilin;
age under 18 years (the safety and effectiveness of the drug for this age group have not been established).

According to the instructions, Anaprilin is prescribed with caution for the following diseases/conditions:

hyperthyroidism;
pregnancy;
myasthenia gravis;
elderly age;
liver and kidney failure;
heart failure;
psoriasis;
history of allergic reactions;
Raynaud's syndrome.

In addition to the positive effects on blood pressure and the heart, the drug Anaprilin has contraindications for use, which include:

Indications for use

What does Anaprilin help with? Taking this medication is necessary for the following diseases and conditions:

hypertension,
pheochromocytoma (used together with α-blockers),
disturbance of heart rhythm due to rheumatic heart disease (tachyarrhythmia, paroxysmal and sinus tachycardia, arrhythmia),
thyrotoxicosis (for additional therapy),
cardiac ischemia,
poisoning with cardiac glycosides, including digitalis preparations,
angina pectoris.

Anaprilin is prescribed for the prevention of migraines and for long-term preventive treatment after myocardial infarction.

Efficacy of the drug

The most pronounced effect of a β-blocker is reflected in its effect on the cardiovascular system. The answer is a negative inotropic, dromotropic, chronotropic, vanmotropic effect on the heart. This means the following impacts:

decreased heart rate;
decreased strength of heart contractions;
reduction in the productivity of the conversion system;
decrease in myocardial excitability.

A decrease in heart rate “knocks down” myocardial oxygen consumption and reduces renal excretion. When a beta blocker is used for a short time, it can cause a decrease in cardiac output and an increase in peripheral resistance. Conversely, long-term use helps reduce peripheral resistance.

A decrease in blood pressure is observed already with a single dose of propranolol: in the 3rd week of regular use of the antihypertensive drug, a stable effect is achieved. In patients with ischemia, the drug reduces the frequency of heart attacks and reduces the need for nitroglycerin. The risk of recurrent heart attack and its consequences and death is reduced by 20–50%.

Composition of the drug

Propranolol is the active component of Anaprilin. There are also tablets with the same name that are needed for the treatment of diseases of the cardiovascular system. Anaprilin contains the following auxiliary elements that do not serve therapeutic purposes:

talc;
milk sugar;
potato starch;
calcium stearate.

"Anaprilin" belongs to a group of blockers of adrenergic receptors located in different parts of the human body: blood vessels, muscles of the heart, bronchi, uterus and prostate gland. The interaction of the drug with sensitive cells prevents the stimulating effect of the nervous system and endocrine glands, which explains its use for idiopathic tremor and endocrinological diseases.

In cardiological practice, the drug is most often prescribed to patients with coronary heart disease. The active substance helps reduce the myocardial oxygen demand and prevents remodeling (restructuring) of the heart muscle. The drug has been proven effective in reducing mortality when taken in the first hours after a heart attack.

The multidirectional effect of the drug on the structures of the body determines its widespread use in medical practice. The instructions for use of "Anaprilin" highlight the following indications for prescribing the medication:

Essential (primary, idiopathic) arterial hypertension is a disease accompanied by persistent excess of standard pressure values for no apparent reason;
coronary heart disease (CHD) – a pathology characterized by impaired blood supply to the myocardium with typical pain in the chest during physical activity;
angina pectoris – a chronic form of coronary artery disease;
hypertrophic cardiomyopathy – a pathology characterized by the proliferation of muscle fibers, which reduces the volume of the chambers of the heart;
rhythm disturbances: atrial flutter or fibrillation (atrial fibrillation), supraventricular tachycardia, extrasystoles;
pheochromocytoma - a tumor of the adrenal tissue that synthesizes catecholamines (adrenaline, norepinephrine);
essential tremor - “trembling” of the hands or other parts of the body for no apparent reason, familial cases are more often recorded;
alcohol withdrawal is a complex of disorders caused by abstinence in people with alcoholism;
infantile hemangiomas - benign tumors of the vascular wall (more common in children);
diffuse toxic goiter and thyrotoxicosis of another etiology (against the background of thyroiditis) are diseases of the thyroid gland, accompanied by increased synthesis of hormones. "Anaprilin" is prescribed as a second-line drug.

In addition, the product is used to prevent migraine attacks, panic attacks and deep anxiety.

The regimen for using “Anaprilin” is determined by the person’s age, disease and severity of the pathology. The average therapeutic doses and frequency of administration of the drug are presented in the table.

Disease	Form	Dose (in milligrams)	Multiplicity
Arterial hypertension	Tablets, capsules	40	2 times a day (if ineffective, increase to 4)
Angina pectoris, arrhythmias	Tablets, capsules	20 – 2 weeks, followed by an increase to 40	3 times a day
Post-infarction state	Tablets, capsules	80	3 times
Paroxysmal arrhythmias, thyrotoxic crises	Solution for intravenous administration	1, after 2 minutes - again	If there is no effect, inject up to 10 times under control of the rhythm and pressure level
Migraine	Pills	40	3 times a day

In obstetric practice, Anaprilin is used to stimulate the onset of labor and prevent hypotonic bleeding in the postnatal period. The dose of the drug is 20 mg 3 times a day for 3-5 days.

"Anaprilin" (active ingredient - propranolol) is a drug that is used for long-term use and emergency care, therefore, for convenience, it is available in different forms.

Release form	Dose of Propranolol
Pills	10 and 40 mg
0.25% solution for intravenous administration 1 mg	2.5 mg per ampoule
1% solution – 5 ml	5 mg per ampoule
Long-acting depot capsules, taken once a day	80 mg

Propranolol is a non-selective (no selective effect on the cardiovascular system) beta-blockers without internal sympathomimetic activity, which causes a wide range of therapeutic effects:

Decrease in heart rate (due to the effect on receptors in the myocardium).
Reducing the oxygen demand of the heart muscle (this is how the antianginal effect of the drug is realized).
Decrease in total peripheral vascular resistance (with long-term use). In the first 2 weeks, there is an increase in the tone of smooth muscle fibers, respectively, in diastolic blood pressure, followed by stabilization and decrease.
Increased tone of smooth muscles of the bronchi (bronchospasm) and uterus (stimulation of labor).
Depressive effect (the drug penetrates the blood-brain barrier and has a direct effect on centers in the brain).
Slows down the processes of iodine metabolism in the body (inhibitory effect on the thyroid gland).
Hypoglycemic effect: blockade of receptors reduces the counter-insular effect of adrenaline and contributes to a drop in blood glucose levels (one of the contraindications of the drug is diabetes mellitus).

"Anaprilin" belongs to the group of lipophilic beta-blockers, which are quickly and in high concentrations absorbed from the gastrointestinal tract. In the blood they combine with proteins: 95% of the drug is in bound form. The drug begins to act after 1 hour (when taking tablets), reaching its maximum concentration within 2 hours.

The duration of the effect of tableted “Anaprilin” is 4-6 hours, which determines the frequency of administration of the drug.

Metabolism and excretion processes occur in the liver, therefore, in patients with dysfunction of the hepatobiliary system, smaller doses of the drug are recommended due to the risk of accumulation and overdose. Less than 1% of the drug is excreted by the kidneys.

Undesirable consequences of using “Anaprilin” are associated with the accumulation of active metabolic products or intake against the background of contraindicated conditions:

orthostatic hypotension – a drop in blood pressure when changing position from horizontal to vertical;
bradycardia (decreased heart rate): frequency reaches 40-50 per minute;
allergic reactions: itchy rash, swelling;
blurred vision (due to decreased secretion of the lacrimal glands);
dry tongue, nausea, vomiting, pain in the upper part and bloating, diarrhea;
redness of the skin, hair loss, the appearance of psoriasis-like peeling;
collapse - a decrease in vascular tone in the arteries of the brain with loss of consciousness;
muscle weakness and numbness of the limbs;
nasal congestion, broncho- or laryngospasm;
hypoglycemia (in patients with diabetes mellitus, propranolol prolongs and enhances the effect of insulin);
headache, weakness, increased fatigue;
sleep disorders (insomnia or pathological daytime sleepiness);
conduction disorders: atrioventricular block.

Main symptoms of poisoning:

dizziness;
severe bradycardia and drop in blood pressure;
loss of consciousness;
difficulty breathing (noisy exhalation);
cyanosis of fingers and toes (in children - faces);
convulsions;
on the electrocardiogram: conduction disturbance in the AV node, frequent ventricular extrasystoles.

The toxic dose is individual for each person, depending on the state of the liver enzyme system and the presence of concomitant diseases. In most cases, symptoms of poisoning develop with the simultaneous use of more than 1 gram of the drug.

According to the instructions for use of the drug, drinking alcohol while taking Anaprilin is not recommended. Toxic exposure occurs due to:

damage to liver enzyme systems by ethanol metabolism products, disturbances in the processes of metabolism and excretion of the drug;
additional inhibitory effect on the central nervous system;
alcohol causes tachycardia and increased blood pressure, which neutralizes the effect of Anaprilin;
increased side effects of the medication (headache, weakness, nausea).

Compatibility of the drug with other substances that affect the nervous system – increased depressive effects.

The dosage form of Anaprilin is tablets. The active substance is propranolol; in 1 tablet its content reaches 10 or 40 mg. Auxiliary components: milk sugar, potato starch, calcium stearate, talc.

The drug contains the active substance propranolol, as well as additional substances: starch, milk sugar, calcium stearate, talc.

Overdose

Now let's look directly at the instructions for Anaprilin - what it helps with, and how much you need to take for various diseases. The drug should be taken 15–30 minutes before meals, washed down with liquid (preferably water). When taking Anaprilin, the dosage and frequency of use (how many times a day to drink) are determined depending on the underlying and concomitant diseases, and the patient’s age.

Arrhythmia - 10-30 mg 3-4 times a day.
Arterial hypertension - you should start taking it with 160 mg (80 mg 2 times a day), if necessary, increasing the dose to 320 mg per day.
Migraine – 80–160 mg per day (80 mg per dose).
Angina pectoris – the first 3 days – 20 mg 4 times a day; the next 3 days - 40 mg 3 times a day and 20 mg 4 times a day. From the seventh, the drug is taken 4 times a day, 40 mg. If necessary, the dosage is increased to 200–240 mg per day (40 mg 5-6 times a day).
Post-infarction state - 160 mg per day (40 mg 4 times a day).

Important! According to medical data, the drug can be taken by a child from 3 years old, a quarter to half a tablet per day. For older children (from 7 years old), the recommended dosage is 0.25–0.5 mg per 1 kg of body weight. Reception – 3-4 times a day.

If the medicine is used correctly and overdose is avoided, according to reviews of people who took Anaprilin, treatment is not associated with complications. Nevertheless, you should periodically monitor the body's reactions to the drug. There is a possibility of dependence and increased susceptibility to the main active substance. In this case, the medicine must be changed.

Anaprilin tablets should be taken half an hour before meals, with plenty of water. The dosage and number of doses depends on the indications, duration of therapy, age of the patient and is determined by a specialist.

The standard treatment regimen for cardiac and vascular abnormalities involves taking the medication for a month. Then the therapy is repeated after a 1-2 month break.
Instructions for use of the drug "Anaprilin" show that for arrhythmia it is necessary to use the drug up to 4 times a day, taking up to 30 mg at a time.
For arterial hypertension, drink 80 mg 2 times. The dosage can be doubled.
For migraine, 80–160 mg is prescribed.
After a heart attack, you need to drink 40 mg of the drug 4 times a day.
For angina pectoris, for the first 3 days you need to take 20 mg of the drug 4 times a day. In the next 3 days, they switch to using a double dose (40 mg) three times a day and drink another 20 mg in the evening. On the seventh day, use 40 mg 4 times.

Children are given the medicine "Anaprilin" only according to strict medical prescriptions after the age of 3 years. The dosage is calculated based on body weight (0.5 per 1 kg of weight).

Doses of the drug are prescribed by the attending physician.

Anaprilin tablets are taken regardless of meals, washed down with a large (at least 200 ml) amount of water.

heart rhythm disturbances, angina pectoris: initial daily dose - 60 mg (20 mg 3 times a day), later the daily dose is increased to 80-120 mg (divided into 2-3 doses). The maximum daily dose is 240 mg;
arterial hypertension: initial daily dose – 80 mg (40 mg 2 times a day), if the hypotensive effect is insufficient, the daily dose is increased to 120–160 mg (40 mg 3 times a day or 80 mg 2 times a day). The maximum daily dose is 320 mg;
essential tremor, migraine prevention: initial daily dose – 80–120 mg (40 mg 2–3 times a day), if necessary, the daily dose can be increased to 160 mg;
prevention of recurrent myocardial infarction: treatment begins between the 5th and 21st day after a heart attack at an initial daily dose of 160 mg (40 mg 4 times a day) for 2 or 3 days, then proceed to a double dose (according to 80 mg 2 times a day).

For pheochromocytoma, the drug is used only in conjunction with alpha-adrenergic receptor blockers.

In case of upcoming surgery, Anaprilin tablets are prescribed for 3 days before surgery at a daily dose of 60 mg.

If renal function is impaired, the initial dose of the drug is reduced or the interval between doses is increased.

If liver function is impaired, it is also recommended to reduce the dose of Anaprilin.

Main symptoms: ventricular extrasystole, marked decrease in blood pressure, dizziness, severe bradycardia, atrioventricular block, fainting, arrhythmia, heart failure (worsening of chronic disease or acute), cyanosis of the palms or fingernails, bronchospasm, difficulty breathing, convulsions.

Therapy: gastric lavage, administration of activated carbon.

Necessary measures determined by indications:

disturbances of atrioventricular conduction: 1–2 mg of atropine intravenously; in case of low effectiveness, placement of a temporary pacemaker is indicated;
bradycardia: 1–2 mg of atropine intravenously; in case of low effectiveness, placement of a temporary pacemaker is indicated;
lowering blood pressure: the patient should be in the Trendelenburg position (lying on his back at an angle of 45° with the pelvis raised in relation to the head);
ventricular extrasystole: lidocaine (the use of class IA drugs is not recommended);
heart failure: diuretics, cardiac glycosides, glucagon;
atrioventricular block: epinephrine, pacemaker setting; in the absence of signs of pulmonary edema, plasma-substituting solutions are administered intravenously; in case of low effectiveness, dopamine, epinephrine, and dobutamine are prescribed;
bronchospasm: β-adrenergic agonists parenterally or inhaled;
convulsions: diazepam intravenously.

Methods of using Anaprilin

According to the indications, Anaprilin in the required doses is prescribed by a doctor; the instructions for Anaprilin indicate the average recommended dosages.

Typically, Anaprilin is used in the form of injections three to four times a day. 10 mg per day before meals (15-30 minutes).

It is also possible to gradually increase the indicated dose if a sufficient effect is not observed. In this case, Anaprilin is given the same three or four times. per day, but 20-40 mg (there are cases when the dose was increased to 200 mg per day).

For arrhythmia, Anaprilin is indicated for use three to four times a day. per day, 0.010-0.030g.

For angina pectoris, the first three days give Anaprilin four times a day. per day, 0.020 g, and in the next 4, 5, 6 - three doses per day, 0.040 g and 0.020 g in the fourth dose. From the 7th day, give 0.040 g of Anaprilin four times. in a day. Afterwards, the use of Anaprilin is continued at 0.16 g per day or the daily dose is increased to 0.20-0.24 g.

For open-angle glaucoma, a 1% solution of Anaprilin is prescribed to lower intraocular pressure.

Intravenous use of Anaprilin is practiced to suppress attacks of angina pectoris and heart rhythm disturbances..

For strict medical indications, Anaprilin is also prescribed to children. They give it three or four rubles. per day, calculating 0.25-0.50 mg per kilogram of the child’s weight.

What diseases does Anaprilin help with?

The drug is recommended for use in the following diseases:

hypertonic disease;
renal hypertension;
angina pectoris;
sinus tachycardia;
tachistostolic form of atrial fibrillation;
supraventricular tachycardia;
extrasystole (ventricular, supraventricular);
disorders of the cardiovascular system as a result of diffuse toxic coronary effects;
tremor;
pheochromocytoma (as a component of complex therapy);
diencephalic syndrome with sympathomadrenal crises;
migraine (prevention of attacks).

Medical appointments include:

atrial fibrillation;
sinus tachycardia;
migraine attacks;
unstable angina;
supraventricular tachycardia;
angina pectoris;
high pressure;
sympathoadrenal crises;
migraine.

With high blood pressure, the medicine helps better young people under the age of 40 in the initial stages of the disease. As systolic pressure decreases, the heart rate decreases and its stroke volume decreases. With ischemia, the body's resistance to physical activity increases. The medication shows good results in the treatment of arterial hypertension and arrhythmia.

Cost and terms of dispensing from pharmacies

Requires a prescription.

In a dark, dry place out of reach of children.

The price of 50 tablets of Anaprilin 10 mg is from 17 rubles.

A prescription is not needed to purchase this drug.

There are contraindications. Specialist consultation required

The average price of Anaprilin (40 mg tablets No. 50) in Moscow is 22 rubles. In Kyiv you can buy medicine for 38 hryvnia, in Kazakhstan - for 110 tenge. In Minsk, pharmacies offer medicine for 0.5 Bel. rubles Dispensed from pharmacies with a prescription.

special instructions

The dosage of Anaprilin and the duration of therapy are determined individually, in accordance with the diagnosis, severity of the disease, and general condition of the person. Patients should be under constant medical supervision, including monitoring of: heart rate, blood pressure, glycemic level (if diabetes is present).

Concomitant diseases requiring careful use of the drug:

bronchitis;
COPD;
controlled heart failure;
diabetes;
depressive disorders;
hyperthyroidism.

For panic attacks, it is recommended to take Anaprilin under the tongue.

The use of Anaprilin simultaneously with hypoglycemic agents is prescribed only under the strict supervision of a physician (to avoid the development of hypoglycemia).

When taken orally, Anaprilin is quickly absorbed and excreted from the body. The half-life of the drug occurs in 3–5 hours, and with long-term use – in 12 hours (90% of the drug is excreted by the kidneys as metabolites, about 1% remains unchanged).

Abrupt discontinuation of the drug can worsen exercise tolerance and increase the risk of developing myocardial ischemia, so you should stop taking Anaprilin gradually and under the supervision of your doctor.

For patients with diabetes mellitus, the drug is prescribed under the control of blood glucose levels.

Taking Anaprilin may affect the ability to concentrate and the speed of motor reactions, therefore, during treatment, precautions should be taken when working with potentially dangerous mechanisms, as well as when driving vehicles.

pharmachologic effect

Propranolol has an antiarrhythmic effect, has a positive effect on the heart during tachycardia, arrhythmia, cardiac pain, and reduces blood pressure by inhibiting adrenergic receptors β-1 and β-2. This reduces myocardial contractility, cardiac output, and increases peripheral vascular resistance. Together with the main effect of propranolol, blocking β-2 receptors increases bronchial tone, uterine contractions, helps stop postoperative and postpartum bleeding, supports the secretion of digestive juices, and motor functions of the gastrointestinal tract.

Anaprilin is well absorbed into the bloodstream. The half-life of propranolol is 3-5 hours; with long-term use of the drug, this time reaches 12 hours. Being absorbed, propranolol is excreted by the kidneys as a metabolite (90%), about 1% remains unchanged.

Indications for the use of Anaprilin - what the medicine helps with in accordance with the instructions for use:

heart rhythm disorders caused by rheumatic heart diseases,
angina pectoris
ischemia,
hypertension,
thyrotoxicosis (as an auxiliary drug),
pheochromocytoma (use in combination with α-blockers).

Important! Anaprilin is often recommended for long-term preventive therapy of post-infarction conditions. The medicine is prescribed for the prevention of migraine (specific attack-like headache).

Use in old age

A doctor can prescribe Anaprilin during pregnancy only in a situation where the threat of not using it is assessed by doctors as higher than the risk of treatment with the drug. During the use of the product, the baby’s condition is strictly monitored. 3 days before the predicted birth, the adrenergic blocker is canceled.

It is impossible to exclude a negative effect on the fetus: bradycardia, hypoglycemia, and developmental delay in the womb may occur. Taking Anaprilin can cause premature birth, as well as, unfortunately, fetal death.

During lactation, the drug is not used (or the patient is asked to stop lactation).

Elderly people should take the drug with great caution. The use of this medication with treatment with hypoglycemic medications is carefully monitored.

Therapy with Anaprilin is contraindicated in patients under 18 years of age.

Therapy with Anaprilin in elderly patients should be carried out under medical supervision.

Contraindications to the use of this drug

The medication should not be used if the following contraindications exist:

Bradycardia.
Hay fever.
Arterial blood flow disorders.
Myocardial infarction, which is in a severe stage.
Diabetes.
Colitis.
When there is an atrioventricular type of blockage, which is accompanied by insufficiency of the activity of the left or right ventricle.

The use of Anaprilin during pregnancy is unacceptable, since currently clinical practice does not have sufficient information confirming the safety of propranolol when used during this period. The use of the medicine is also contraindicated during the lactation period, since the components can pass into breast milk.

The drug should not be used for bronchial asthma, in parallel with tranquilizers.

It is strictly forbidden to drink drinks containing alcohol during therapy with Anaprilin, since ethanol and propranolol are incompatible substances. Such a combination can cause complications, including death, and the therapeutic effectiveness of the drug is minimized. When taking alcohol and propranolol in parallel, the patient immediately develops the following negative symptoms: vomiting and nausea, chills, decreased blood pressure, and fainting.

It should be noted that therapy with Anaprilin, which contains propranolol, can provoke an exacerbation and worsening of psoriasis. This must be taken into account by patients suffering from this pathology.

Analogues of "Anaprilin" should be selected by a doctor.

Use by children, pregnant and lactating women

During pregnancy, the medicine is prescribed only if the expected benefit to the woman outweighs the potential risk to the fetus. When using Anaprilin, fetal control is required! Stop taking the drug 3 days before giving birth! Possible negative effects on the fetus:

bradycardia;
hypoglycemia;
intrauterine growth retardation.

The medicine may cause fetal death or premature birth due to increased uterine contractions. The active substance of the drug passes into breast milk, so lactation should be interrupted during treatment. For children, the drug is prescribed only in accordance with medical indications.

The drug "Anaprilin" - for what? The action of the drug "Anaprilin"

Quite often, doctors prescribe the drug "Anaprilin" to their patients. What does it help you get rid of? What does it represent? Are there any contraindications to taking this medication? These questions interest many patients.

The drug "Anaprilin": release form and composition

Today, the medicine is available in the form of small tablets, but there is also an injection solution, which, however, is used much less frequently.

The main active substance of the drug is propranolol hydrochloride. Each tablet contains either 10 or 40 mg of this component. Of course, auxiliary substances are also used in production: colloidal silicon dioxide, talc, calcium stearate, corn starch, and microcrystalline cellulose.

Pharmacological properties of the drug

This medicine is a non-selective beta blocker. The active component of this drug weakens the effect of sympathetic impulses on myocardial beta receptors. Thus, there is a decrease in the frequency and strength of heart contractions, as well as neutralization of the effects of catecholamines. The drug reduces the need for oxygen in the heart muscle. Under its influence, a decrease in blood pressure is observed.

But the effect of “Anaprilin” does not end there. For example, immediately after taking the medicine, the tone of the bronchial muscles increases, as well as the contractility of the uterus. In addition, there is an increase in the motor and secretory activity of the digestive system.

After administration, the tablet quickly dissolves in the digestive tract, after which the active components enter the blood. The maximum concentration of propranolol is observed 1-1.5 hours after administration. The drug is excreted in the form of metabolites by the kidneys. The half-life is 3-5 hours. Only with long-term use can the substance remain in the blood for up to 12 hours.

Indications for use

Of course, today many patients are prescribed the drug "Anaprilin". What does this remedy help with? To begin with, it is worth noting that the main indication for its use is diseases of the cardiovascular system, accompanied by an increase in blood pressure. For example, it is prescribed to people suffering from chronic arterial hypertension, as well as atrial fibrillation and sinus tachycardia.

In some cases, the drug is used for mitral valve prolapse, as well as neurocirculatory dystonia, hypertrophic cardiomyopathy and myocardial infarction.

There are other cases in which the drug “Anaprilin” is used. What else does it help with? Sometimes the medicine becomes an excellent prevention of severe migraine attacks. In combination with other drugs, it is used to treat withdrawal symptoms. It is also known that treatment of hemangioma with Anaprilin is also often successful, and in the initial stages it even helps to avoid surgical intervention. And although the drug was not developed specifically for these purposes, in modern surgery it is often prescribed even to children.

Tablets "Anaprilin": instructions for use

It is best to take the tablets 10-30 minutes before meals, preferably with plenty of liquid. It’s worth noting right away that only your attending physician can prescribe you the drug “Anaprilin”. The dose here is determined individually.

As a rule, treatment begins with 10 mg of propranolol per day. If the medicine is well tolerated, then the daily amount is gradually increased to 80-100 mg, divided into four doses. In some cases (if the drug does not cause adverse reactions and the therapeutic effect is weak), the dose can be increased to 180-300 mg, divided into 4-6 doses.

The duration of therapy is also determined separately for each patient, but, as a rule, the course of treatment is 3-4 weeks. In some cases, doctors recommend taking a break for two months, and then repeating it again.

If we are talking about arrhythmia or coronary artery disease, then beta blockers are taken much longer. But in this case, gradual withdrawal of the medication is extremely important. If you stop taking it abruptly, severe and dangerous complications are possible.

Contraindications to treatment

Of course, in this case the therapy has some contraindications. In particular, the drug is not used to treat patients with complete or partial atrioventricular or sinoatrial block. In addition, a contraindication for use is sinus bradycardia, in which the heart rate does not exceed 50 beats per minute. The medicine should not be given to patients suffering from arterial hypotension.

The drug is contraindicated for people with certain diseases of the respiratory system. For example, it should not be taken by patients with severe bronchial asthma, as well as people with a tendency to bronchospasm. Obliterative peripheral vascular diseases, as well as Raynaud's syndrome and diabetes mellitus are also considered contraindications.

Are there any possible side effects?

In fact, there are a number of disorders that may appear while taking the drug "Anaprilin". What should you insure against? What to look for? Most often, the medicine causes disorders of the digestive system. For example, some patients complain of severe nausea, which is often accompanied by vomiting, as well as pain in the epigastric region. Diarrhea is also possible. More serious side effects occur much less frequently, including various liver dysfunctions, as well as ischemic colitis.

Occasionally, allergic reactions are observed, accompanied by itching, redness and hives. In some cases, during therapy, exacerbation of psoriasis, as well as baldness, is observed. Taking the drug may cause problems with the respiratory system, including bronchospasm, laryngospasm, as well as severe cough and shortness of breath.

From the circulatory system, side effects such as bradycardia and arterial hypotension are possible. In addition, the drug can affect the functioning of the nervous system, causing anxiety, insomnia and nightmares. Headaches and dizziness may occur. It is much less common for patients to develop clinical depression.

The drug "Anaprilin": overdose, its symptoms and treatment methods

Taking too much of a medicine can affect the functioning of the entire body. In particular, symptoms include severe dizziness and weakness. Often there is a pronounced decrease in blood pressure, as well as arrhythmia, bradycardia and other disorders of the circulatory system, including the development of heart failure.

There are other disorders that can be caused by taking a large amount of the drug “Anaprilin”. An overdose may be accompanied by difficulty breathing and bronchospasm. Sometimes convulsions and collapse are observed.

A person with these symptoms should be taken to the emergency department immediately. If possible, induce vomiting. As first aid, doctors perform gastric lavage and prescribe adsorbents to patients. Further treatment directly depends on how severe the damage was caused. For example, for heart failure, glycosides are used, and for seizures, the drug Diazepam is indicated.

Interaction with other drugs

The active components of this medicine may interact with other medications. For example, the hypotensive properties of propranolol are enhanced by the simultaneous introduction of anesthetics, sympatholytics, monoamine oxidase inhibitors and hydralazine into the body. But the presence of hormonal drugs in the blood (in particular, estrogens and glucocorticosteroids), as well as non-steroidal anti-inflammatory substances, on the contrary, reduces the effect of taking Anaprilin tablets. With the introduction of radiocontrast agents, the likelihood of developing anaphylactic reactions significantly increases. Therefore, you must tell your doctor about all the medications you are taking.

Can the medicine be used during pregnancy?

It’s worth noting right away that the use of the drug “Anaprilina,” as well as almost any other beta blocker, is contraindicated during pregnancy. The fact is that this medicine reduces the level of placental perfusion, which in turn increases the risk of fetal death or premature birth. In some cases, maternal use of the drug leads to the development of bradycardia in the fetus. There is a high probability of various complications in the postpartum period, in particular from the respiratory and cardiovascular systems.

A doctor can prescribe this medicine to a pregnant patient only if the expected benefit to her outweighs the possible risk to the baby. By the way, the main components of the medicine can also pass into breast milk, so the lactation period is also a contraindication.

Additional information about the drug

Today, many people are interested in questions about what the drug “Anaprilin” is, instructions for use, price, possible side effects. And it’s immediately worth noting that specialists categorically prohibit drinking alcohol during therapy. The fact is that alcohol together with pills can lead to a sharp, life-threatening decrease in blood pressure.

The drug should be stored in a dry, warm place, protected from direct sunlight at a temperature not exceeding 25 degrees Celsius.

As for the cost of the medicine, it ranges from 40 to 100 rubles. By the way, you can buy Anaprilin tablets in almost any pharmacy; you don’t need a doctor’s prescription for this. The drug also has analogues, in particular the products “Inderal”, “Propamin”, “Stobetin” and some others.

fb.ru

Drug interactions

Treatment with Anaprilin is prohibited for the following diseases and conditions:

acute form of heart attack and heart failure;
cardiogenic shock;
asthma and predisposition to the development of bronchospasm;
acidosis;
pathologies of peripheral circulation;
sinus bradycardia (when the heart beats less than 55 beats per minute);
complete and partial atrioventricular block;
uncontrolled heart failure;
colitis of a spastic nature;
chronic liver diseases;
diabetes mellitus;
Raynaud's disease;
hypersensitivity to the components of the drug;
pregnancy and lactation;
low pressure;
vasomotor rhinitis.

Drivers and representatives of other professions that require extreme concentration should refrain from taking this medication, as it reduces the ability for quick mental and motor reactions.

Side effects

Anaprilin is well tolerated. However, side effects may occur, which include:

agranulocytosis, leukopenia and thrombocytopenia from the hematopoietic system,
malaise, dizziness and headache, depression, sleep problems, mental disorders, decreased speed of motor and psychomotor reactions from the nervous system,
deterioration of blood circulation and the development of heart failure, obvious arterial hypotension and sinus bradycardia,
decreased libido and decreased potency,
rash, alopecia, itching and worsening of psoriasis,
cough, pharyngitis, shortness of breath, laryngospasm and bronchospasm,
soreness and dryness of the eyes, decreased vision, keratoconjunctivitis,
dyspepsia (vomiting, nausea and diarrhea), pain in the epigastric region.

If these and other undesirable symptoms appear, you should immediately stop taking the drug and consult a doctor.

Medicines analogues of Anaprilin

The main active ingredient of Anaprilin is the synthetic substance propranolol hydrochloride. Anaprilin analogues in accordance with the structure (containing a similar active substance) are as follows:

Propranolol;
Propranoloben;
Noloten;
Stobetin;
Propylamine;
Obzidan.

Since these drugs are identical in composition, they are interchangeable with regard to indications, contraindications, and side effects.

There are also Anaprilin analogs that differ in composition. These are drugs belonging to a similar pharmacological group (β-blockers), which have similar properties, but contain other active substances.

Also, the modern pharmaceutical market presents safe drugs with a similar mechanism of action - selective β-blockers. These drugs, unlike the non-selective Anaprilin, block the functioning of certain types of β-adrenergic receptor organs. They do not affect other organs, which means the number of possible side effects is significantly reduced.

These drugs differ in terms of bioavailability, duration of effect, absorption and a number of other indicators. The decision to use any drug in therapy is made by the doctor based on the results of diagnostic studies, the characteristics of the patient’s body, and tolerance to pharmaceuticals.

Pharmacodynamics and pharmacokinetics

The main active ingredient is propranolol. Anaprilin is a non-selective adrenergic blocker, reduces the sympathetic effect on beta-adrenergic receptors of the heart, reduces the frequency and strength of heart contractions, reduces the contractile function of the myocardium, regulates cardiac output downwards, blocks the positive inotropic and chronotropic effect of catecholamines, reduces the heart's need for oxygen, reduces arterial pressure.

When taken orally, the drug is quickly absorbed and excreted from the body. The maximum peak content of the active substance in the blood plasma is recorded after 1 -1.5 hours. The drug penetrates the fetoplacental barrier.

Contraindications and precautions

Anaprilin 40 mg and even 10 mg are strictly not recommended for use in a number of pathologies. The main ones are:

Persistent hypotension with blood pressure less than 90 mmHg.
Chronic bradycardia (heart rate does not reach 55 beats/minute).
Cardiac ischemia from stage II.
AHF (acute myocardial pathology).
Cardiogenic shock.
AV block - II or III degree.
Raynaud's disease.
Intolerance to propranolol.

Caution should be exercised when prescribing this medication if the patient suffers from any chronic obstructive diseases of the lungs and bronchi, and there is a history of bronchospasm. For vasomotor rhinitis, acidosis caused by metabolic disorders, and obliterating pathologies of the vascular system, you should think about choosing another remedy. When prescribing Anaprilin to diabetics, there is a high risk of developing hypoglycemic coma. The use of the medicine is permitted only under strict medical supervision for persons with serious damage to the liver and kidneys.

A special group of patients consists of pregnant and lactating women, but in some cases the described adrenergic blocker is still prescribed. But it is better to avoid this, because propranolol can negatively affect the fetus, causing a delay in its development, a decrease in blood sugar levels and a decrease in heart rate. If Anaprilin is still prescribed to a pregnant woman, then its use should be stopped at least 48 hours before the onset of labor. If you need to use this particular medication during breastfeeding, you should stop breastfeeding your baby.

In case of accidental intake of a large dose of the drug, it is necessary to perform a gastric lavage, take a sorbent and consult a doctor. The rest of the treatment is prescribed by a specialist. Symptoms of an overdose of Anaprilin depend on its amount in the blood. In case of mild poisoning, dizziness, a sharp drop in blood pressure, bradycardia, drowsiness, and dyspepsia may occur. In a severe case, circulatory disorders, a critical decrease in pressure, fainting, and collapse are likely. There is a high risk of respiratory arrest and death of the patient.

Even with proper use of the medicine, unpleasant side effects on internal organs and systems may occur. This is expressed in a decrease in heart rate and chest pain, nausea, dyspepsia, epigastric discomfort, swelling of the nasal mucosa and bronchospasm. Taking the medication may be accompanied by skin reactions that mimic psoriasis, excessive sweating, itching and rashes. There are other, less common, but equally unpleasant reactions of the human body to the use of the described medication.

Side effects

If you look at the list of adverse events in the instructions, you may get the impression that the treatment is worse than the disease itself. But not everything is so tragic.

When used correctly, in compliance with contraindications and usage patterns, the likelihood of negative consequences is minimal.

What are the most common side effects:

Neurological disorders. Headache, spatial disorientation. Drowsiness, weakness, fatigue.
Burning with dryness in the eyes.
Allergic reactions. Usually in the form of a skin rash. Others are much less common.
Fall in blood pressure, bradycardia. In exceptional situations - cardiac arrest, worsening cardiac dysfunction. But these are more isolated cases than a natural result. Therefore, there is no need to worry.
Dyspeptic phenomena. Nausea, vomiting, abdominal pain, heartburn, heaviness, indigestion. Temporarily. Disappears within a few days from the start of therapy.
Side effects of Anaprilin on the skin include hyperhidrosis (increased sweating) and a rash of non-allergic origin. Psoriatic type.

It is important to keep in mind that Anaprilin is characterized by withdrawal syndrome. The opposite phenomena develop: an increase in blood pressure, heart rate, and others.

Therefore, you need to stop taking it by gradually reducing the dosage. You can't throw it suddenly.