Which medicine is better Terzhinan or Metromicon-neo?

Anzhero-Sudzhensky HFZ, LLC Pharmaprim LLC

Country of origin

Moldova, Republic of Russia

Product group

Antifungal drugs Combined antimicrobial agent (antimicrobial and antiprotozoal agent + antifungal agent)

Release forms

vaginal suppositories 14 pieces per pack

Description of the dosage form

White or white with a yellowish tint, torpedo-shaped suppositories. An air rod or funnel-shaped depression is allowed on the cut.

pharmachologic effect

Metromicon-Neo is a combined drug with antiprotozoal, antifungal and antibacterial effects. Contains metronidazole and miconazole. Pharmacodynamics. Metronidazole belongs to the 5-nitroimidazoles and is a drug with a bactericidal type of action that exhibits tropism (the ability to interact) with deoxyribonucleic acid. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the deoxyribonucleic acid of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against protozoa: Trichomonas vaginalis, Entamoeba histolytica, as well as obligate anaerobic bacteria: gram-negative Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), gram-positive - Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp. and facultative anaerobe – Gardnerella vaginalis. Aerobic microorganisms are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics that are effective against common aerobes. Miconazole is an azole derivative antifungal agent. When used intravaginally, it is active mainly against Candida albicans. The fungicidal and fungistatic effect of miconazole is due to inhibition of the biosynthesis of ergosterol in the membrane and plasma membranes of fungi, changes in the lipid composition and permeability of the cell wall, causing the death of the fungal cell.

Pharmacokinetics

Compared with oral administration, the bioavailability of metronidazole when administered intravaginally is 20%. Metronidazole is metabolized in the liver. Hydroxyl metabolites are active. The half-life of metronidazole is 6–11 hours. About 20% of the dose is excreted unchanged in the urine. When administered intravaginally, miconazole is absorbed slightly and is not detected in plasma.

Special conditions

When using the drug, you should abstain from sexual intercourse. In order to avoid re-infection, simultaneous treatment of the sexual partner is necessary. In the case of trichomonas vaginitis, it is advisable to simultaneously treat the sexual partner with metronidazole for oral administration. During treatment and for at least 24-48 hours after the end of treatment, ethanol should be avoided (ethanol intolerance is possible). The simultaneous use of the drug with contraceptive diaphragms and rubber or latex condoms is not recommended (possible interaction with the suppository base). If there is severe irritation of the vagina, treatment with the drug should be discontinued. Suppositories should only be used intravaginally and should not be swallowed or used in any other way. If the drug is used together with metronidazole for oral administration, especially with a repeated course, monitoring of the peripheral blood picture is necessary (danger of leukopenia). Impact on the ability to drive vehicles and control potentially dangerous mechanisms: caution is recommended, since a possible negative impact on the ability to drive a vehicle and control complex mechanisms cannot be excluded. If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

Compound

One suppository contains: active ingredients: metronidazole 500 mg, miconazole nitrate 100 mg; excipients: semi-synthetic glycerides (Suppotsir AM) - sufficient quantity to obtain a suppository weighing 2000 mg.

Metromicon-Neo indications for use

Vaginal infections: vaginal candidiasis; trichomonas vaginitis and vulvovaginitis, bacterial vaginosis; mixed vaginal infection.

Metromicon-Neo contraindications

Hypersensitivity to the components of the drug or other nitroimidazole derivatives, pregnancy, lactation.

Metromicon-Neo dosage

500 mg + 100 mg

Metromicon-Neo side effects

Local reactions: burning, itching, irritation of the vaginal mucosa and increased swelling. Due to inflammation of the vaginal mucosa during vaginitis, irritation may increase after the introduction of the first suppository or by the third day of treatment. These complications disappear quickly after stopping treatment. From the gastrointestinal tract: abdominal pain or cramps, “metallic” taste, dry mouth, constipation, diarrhea, loss of appetite, nausea, vomiting. From the nervous system: headache, motor disorders (ataxia), dizziness, psycho-emotional disorders, convulsions. From the hematopoietic system: leukopenia. Allergic reactions: skin rashes, including urticaria.

Drug interactions

Due to the entry of metronidazole into the systemic circulation, the following interaction reactions may occur when used simultaneously with certain substances: Oral anticoagulants: the effect of indirect anticoagulants is enhanced. Disulfiram: central nervous system disorders (mental reactions) may occur; Metronidazole should not be prescribed to patients who have taken disulfiram within the last 2 weeks; Phenytoin: the concentration of phenytoin in the blood increases, and the concentration of metronidazole in the blood decreases. Lithium preparations: increased toxicity may occur. Phenobarbital: the concentration of metronidazole in the blood decreases. Cimetidine: The concentration of metronidazole in the blood may increase. Astemizole and terfenadine: Metronidazole and miconazole inhibit the metabolism of these drugs and increase plasma concentrations. Ethanol: The interaction of metronidazole with ethanol causes disulfiram-like reactions.

Overdose

If the recommended doses are observed, due to the low absorption of the drug, cases of overdose have not been identified. Possible symptoms: nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste in the mouth, ataxia, dizziness, paresthesia, peripheral neuropathy (with prolonged use in high doses), convulsions, leukopenia, dark coloration of urine (due to an overdose of metronidazole). No symptoms of miconazole overdose have been identified. Treatment: symptomatic and supportive therapy, in case of accidental ingestion - gastric lavage.

Storage conditions

store in a dry place
keep away from children
store in a place protected from light

Information provided
Additional components:

semi-synthetic glycerides necessary to obtain a suppository weighing 2000 mg.

pharmachologic effect

Antimicrobial, antiprotozoal and antifungal agent

. The active component Metronidazole has a bactericidal effect and belongs to the 5-nitroimidazoles. Capable of interacting with deoxyribonucleic acid. The mechanism of action is based on the reduction of the 5-nitro group of metronidazole at the biochemical level by transport intracellular proteins, proteins of protozoa and anaerobic bacteria.

After the reduction process, the 5-nitro group interacts with the deoxyribonucleic acid of the microbial cell, suppressing the synthesis of nucleic acids, which causes the death of the microorganism.

Metromicon candles

have a detrimental effect on gardnerella (facultative anaerobe), gram-positive bacteria, trichomonas, gram-negative microorganisms. Anaerobes show resistance to metronidazole, but in relation to mixed flora in combination with antibiotics, synergism and suppression of the activity of ordinary aerobes are observed.

The second component Miconazole is an azole derivative and exhibits antimycotic activity

. Intravaginal use suppresses the activity of Candida albicans. By inhibiting the biological synthesis of ergosterol in plasma membranes and fungal cell membranes, disrupting the permeability of the cell wall and lipid composition, fungistatic and fungicidal effects are achieved.

Side effects

Local reactions:

swelling of the vaginal mucosa;
burning;
irritation of mucous membranes.

On the first day of therapy for vaginitis (or by the third day), irritation and inflammation of the vaginal mucous membranes may increase.

Negative symptoms go away on their own upon completion of the course.

Digestive tract:

loss of appetite;
metallic taste in the mouth;
epigastric spasms;
stomach ache;
vomit;
nausea.

Nervous system:

convulsive syndrome
;
psycho-emotional disorders;
ataxia and other movement disorders;

Other reactions:

leukopenia;
rashes on the skin.

Metromicon-neo

bactericidal drugs . Endowed with antiprotozoal, antibacterial, antifungal properties. The mechanism of action is due to the suppression of the layer of molecules covering fungal cells, changes in the fat composition and permeability of the walls, which leads to the elimination of the infection. Available in the form of vaginal suppositories.

Indications for use are vaginal infections, namely:

Vaginal mycosis, caused by microscopic yeast-like fungi of the genus Candida.
Trichomonas colpitis.
An inflammatory disease of an infectious nature, characterized by damage to the vulva.
Vaginal dysbiosis.
Vaginal infections of mixed etiology.

Contraindications include:

Increased sensitivity of active and auxiliary components.
The first three months of pregnancy, lactation.
Persons under eighteen years of age.
Virginity.

Caution should be exercised in case of problems with the liver, kidneys, pigment metabolism disorders, pathologies of the central nervous system, diabetes mellitus, and impaired outflow of blood and lymph. In the second and third trimester of pregnancy, use is allowed only under the strict supervision of a doctor if the benefit of therapy outweighs the potential risk to the fetus. If you are breastfeeding, lactation should be stopped, since the active ingredient can leak into milk.

Adverse reactions may include:

Feeling of irritating sensation of heat in the genitals, itching, swelling.
Pain, stomach cramps, decreased saliva production, metallic taste in the mouth, decreased appetite, nausea, bowel dysfunction.
Head pain, deterioration of motor functions, disorientation in space, mental instability.
Decrease in the number of leukocytes.
Allergic manifestations accompanied by rashes on the body.

Metromicon-Neo suppositories, instructions for use (Method and dosage)

Torpedo-shaped suppositories are inserted intravaginally. Using scissors, cut the contour packaging, release the suppository and insert deeply into the vagina.

Instructions for Metromicon suppositories for bacterial vaginosis:

1 suppository at night. Course – 7 days.

For chronic vaginitis

Therapy is carried out for 2 weeks, suppositories are administered before bedtime.

For vaginitis with often recurrent course

Reviews about Metromicon-Neo

Gynecologists quite often prescribe medication as part of complex therapy for most gynecological diseases of infectious origin. Reviews of Metromicon-Neo suppositories from medical workers and patients are positive: the drug is easy to use, well tolerated, quickly relieves the negative and unpleasant symptoms of vaginitis and candidiasis, relieving itching, burning and discomfort in the vagina.

The combined composition of the medication significantly expands the range of its use: fungal, protozoal and microbial infections of the vagina. The advantage of the drug is its reasonable price in comparison with similar drugs.

The medication can be used during pregnancy according to indications. On forums, nursing mothers note that during treatment the milk becomes bitter, so it is recommended to interrupt lactation while undergoing the full course of treatment.

Overdose

Low absorption of active components eliminates overdose if recommended treatment regimens are followed.

The possible clinical picture consists of the following negative symptoms:

dark coloration of urine;
convulsions;
paresthesia;
epigastric pain;
vomit;
nausea;
peripheral neuropathy;
skin rashes;
ataxia;
dizziness;
leukopenia.

If ingested, adequate syndromic therapy is carried out.

Interaction

Metronidazole enters the systemic circulation and may interact pharmacologically with other medications. Metromicon-Neo enhances the effects of indirect-acting anticoagulant drugs.

During treatment, disturbances in the functioning of the nervous system may be recorded in the form of various mental reactions. It is recommended to maintain a 2-week break between doses.

Concomitant therapy with Phenytoin

leads to an increase in the concentration of the latter and a decrease in the level of Metronidazole in the blood. The drug increases the toxicity of Li preparations. Phenobarbital can reduce the level of metronidazole in the blood.

The opposite effect is recorded during treatment .

Ethanol provokes the development of disulfiram-like negative reactions.
Metromicon-Neo suppresses the metabolism of Astemizole
and increases their concentration in plasma.

special instructions

Treatment with a combination drug requires complete abstinence from sexual intercourse. Parallel treatment of the partner helps prevent re-infection. For trichomonas vaginitis, the partner is recommended to take Metronidazole orally.

Drinking alcohol-containing drinks is prohibited. Latex and rubber condoms and contraceptive diaphragms are not recommended for use during treatment with Metromicon-Neo.

If irritation in the vagina progresses, treatment is stopped. Suppositories should not be used orally or otherwise except intravaginally. Taking Metronidazole orally while administering suppositories requires monitoring all blood indicators due to the high risk of developing leukopenia.

Metromicon-Neo price, where to buy

The cost of suppositories depends on the region of sale and pharmacy chain.

The average price of Metromicon-Neo candles in Russia is 400 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Metromicon-neo supp. vagina. 500 mg 100 mg No. 14 FARMAPRIM LLC / Avexima Siberia LLC

Pharmacy Dialogue

Metromicon-Neo (supp.vag.500mg 100mg No. 14)
Metromicon-Neo suppositories vaginal 500 mg 100 mg No. 14

BIOSPHERE

Metromicon-neo No. 14 sup.vag.Farmaprim SRL (Moldova)

For children

Metromicon-Neo is not used in pediatric practice.

"Metromicon-Neo" is a combination drug based on two active ingredients with antifungal and antibacterial effects: metronidazole and miconazole.

The product is actively used in gynecological practice to combat diseases of the genital area, including vaginitis and vaginal bacteriosis.

When is it appointed?

Indications for prescribing the drug are fungal and bacterial infections of the genitals and vagina, as well as mixed genital infections. Most often, Metromicon-Neo is used to treat the following conditions:

vaginal candidiasis;
vaginal trichomoniasis;
vaginitis (acute and chronic);
vulvovaginitis;
vaginal bacteriosis;
mixed genital infections.

Important!

The drug is ineffective for treating infections caused by aerobic organisms, but when taken simultaneously with antibiotics, Metromicon-Neo enhances their effect (with a mixed type of pathogenic flora) and suppresses the growth of pathogenic bacteria.

How to use?

Metromicon-Neo suppositories are inserted deep into the vagina. At the entire stage of treatment, it is necessary to monitor the hygiene of the intimate area. Immediately before inserting the suppository, it is recommended to hygienically wash and treat your hands (with an antiseptic or disinfectant solution).

To achieve a therapeutic effect, use 1 suppository per day. The recommended time for the procedure is just before bedtime. After inserting the suppository, you should remain in a horizontal position for at least half an hour.

The duration of treatment depends on the diagnosis and the severity of symptoms. Standard treatment periods are as follows:

acute vaginitis – 7 days;
chronic vaginitis – 14 days;
vaginal bacteriosis – 7 days;
thrush (vaginal candidiasis) – 7 days.

In case of relapses, as well as the absence of results from the treatment, it is recommended to use the drug for at least 14 days.

Contraindications

Absolute contraindications for the use of Metromicon-Neo suppositories are:

first 12-14 weeks of pregnancy;
lactation;
integrity of the hymen;
age under 18 years;
hypersensitivity to ingredients;
allergy to the components of the medicine.

The attending physician, after a thorough assessment, may limit the use of the drug if there is a history of the following diagnoses (due to an increased risk):

kidney and liver diseases/partial dysfunction of these organs;
pathologies of the nervous system;
impaired microcirculation;
hematopoietic disorder;
diabetes;
porphyria (pigment metabolism disorder).

Pregnancy and lactation

In exceptional cases, Metromicon-Neo can be used to treat pregnant women in the second and third trimester in cases where there is no safe alternative or there is no positive dynamics from the use of other methods. Pregnant women should be under the supervision of a gynecologist or obstetrician throughout the entire period of treatment.

Lactation is a contraindication for the use of the drug, since metronidazole is excreted into breast milk. If use is necessary, breastfeeding should be discontinued. Resumption of lactation should occur no earlier than 24-48 hours after completion of therapy - this is the period of complete elimination of metronidazole from the body.

Overdose

With accidental use of large dosages of the drug, as well as with long-term therapy, systemic effects may occur, for example, a metallic taste in the mouth, headache, dyspepsia, and digestive disorders.

Treatment is symptomatic and does not require discontinuation of treatment.

Side effects

Side effects that occur during treatment with Metromicon-Neo suppositories can be divided into two groups: local (appear only at the site of use) and systemic (associated with the functioning of internal organs, which is affected by the absorption of active components).

Local side effects

irritation (flaking, dryness);
rash;
burning and tingling;
allergic reactions (urticaria).

Systemic side effects:

constipation or diarrhea;
nausea;
loss of appetite;
taste disturbance;
leukopenia;
convulsions;
headache, dizziness (very rarely - loss of consciousness);
psychoses and neuroses (moderately expressed);
lack of coordination.

Important!

In case of negative reactions of high intensity, the use of the drug should be stopped and consult your doctor.

Composition and pharmacokinetics

"Metromicon-Neo" consists of three ingredients:

The drug is available in the form of white vaginal suppositories with a depression at the end (14 pieces per package). The average cost is 314 rubles per pack.

The bioavailability of metronidazole when administered intravaginally is 20%. The substance is metabolized in the liver and excreted from the body mainly in the urine (half-life is from 6 to 11 hours).

Miconazole is practically not absorbed by mucous membranes and is not found in the systemic circulation.

Description and Instructions for Use Metromicon Neo

Metronidazole and miconazole are used as active substances in the suppository, and semi-synthetic glycerides are used as auxiliary substances. The drug has a pronounced antibacterial, antiprotozoal and antifungal effect. Used in gynecology to treat vaginal infections:

vaginal candidiasis;
trichomonas vaginitis and vulvovaginitis, bacterial vaginosis;
with mixed vaginal infection.

Each disease requires a special dosage and regimen. Suppositories are used exclusively intravaginally according to the following scheme:

acute vaginitis and bacterial vaginosis - 1 suppository in the mornings and evenings for a week;
chronic vaginitis – 1 suppository once a day, for two weeks immediately before bedtime;
recurrent vaginitis or lack of positive dynamics with another form of treatment - 1 suppository in the mornings and evenings for two weeks.

Side effects

Sometimes the drug can cause burning and itching, some swelling and irritation of the vaginal mucosa. With vaginitis, irritation intensifies due to the inflammatory process on the mucous membrane, this usually occurs after the first injection of a suppository or after several days of treatment. Such local reactions quickly disappear after stopping the use of suppositories.

Gastrointestinal tract – lack of appetite, metallic taste or dry mouth, constipation, diarrhea, vomiting and nausea, abdominal cramps.
Nervous system – headaches, movement disorders, seizures, mental and emotional disorders.
Allergic reactions - skin rashes, urticaria.
Hematopoietic system – danger of leukopenia.

Contraindications

There are some contraindications to the use of the drug:

hypersensitivity to the components of the drug;
the first part of pregnancy and lactation period;
age under 18 years;
virginity.

Reviews

(Leave your feedback in the comments)

I stubbornly treated thrush for six months, but it kept coming back (as in the famous advertisement). When I finally decided to go to another doctor and undergo a full examination, it turned out that the disease had already entered the chronic stage. The doctor prescribed me douching and Metromicon-Neo suppositories. The candle has a convenient shape and is pleasant to the touch, although this is not very important, because the main thing is the result. I used the entire package (14 pieces) 1 candle per day. In addition, she followed all the gynecologist’s instructions regarding hygiene (boiled and ironed the bed linen along with the underwear, used a special gel for washing to normalize the vaginal flora). Two weeks later, I found out that my pain had gone away without a trace.

And I was not spared such dubious happiness. Like thrush. Some French suppositories were prescribed for treatment, but they were not available at the pharmacy, and the pharmacist recommended Metromicon-Neo. They turned out to be a generic (a substitute with a completely identical composition) of the medicine prescribed to me, although they cost almost 5 (!!!) times less. Despite the fact that the instructions indicate to use 1 suppository per day, for some reason I was prescribed them 2 times a day. Well, okay, as long as it helps. The candles are small in size and convenient. They may leak after insertion, so you should not get out of bed for at least half an hour - during this time the composition will have time to be absorbed by the walls of the vagina. Among the side effects, I had a slight tingling sensation, but it went away within 15-20 minutes after using the medicine. It took me 8 days to completely get rid of thrush. I hope that this dirty trick will not affect me again. And if it does, now I know how I will treat it.

* — Average value among several sellers at the time of monitoring, is not a public offer